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Ferroptosis is closely associated with iron homeostasis dysregulation, redox imbalance, and oxygen-dependent degradation of membrane lipids enriched in polyunsaturated fatty acids (PUFAs) (Jiang et al., 2021a)

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Interestingly, the treatment of macrophages with MK-801, an NMDAR antagonist, showed similar results to that observed with ketamine, suggesting that ketamine and MK-801 could induce beneficial effects by the activation of NMDAR in depressive disorders (128)